Magnium and potassium-sparing diuretic and aldosterone antagonist. It competitively associates with aldosterone receptors in in the distal parts of the nephron. It has a diuretic effect, increases excretion of natrium ions and decreases excretion of potassium and magnium, decreases urinary acidity. The diuretic effect of the medicine is moderate and appears usually after 2-5 days of treatment and continues during 2-3 days after discontinuance of the medicine intake. A weak hypotension effect appear usually in 2-3 weeks of treatment. Aldactone is used in combination with other drugs to treat hypertension. It also facilitates removal of excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.

Dosage and direction

Daily dose for adults in arterial hypertension, edema syndrome is 50-100 mg for adults. It should be divided into 1-2 intakes a day. On necessity the dose maybe gradually increased up to 200 mg a day. Duration of treatment is not less than two weeks. For other conditions such as chronic congestive heart failure, cirrhosis, nephrotic syndrome and others different dosage maybe recommended. Consult your doctor before you decide to take this medicine. Aldactone should be taken after a meal and the most preferable is a single dose before bedtime.

Precautions

Do not drink alcohol as it increases some of the side effects of Aldactone. Avoid eating too much salt because excess of alt maybe cause your body to retain water and effectiveness of Aldactone decreases. It is recommended not to take salt substitutes or low-sodium milk products which contain potassium. Avoid becoming overheated or dehydrated during exercising. Talk with your doctor about amount of liquids you should consume. Do not stop using this medicine even if you feel improvement of youth health if you are being treated for high blood pressure.

Contraindication

Hypersensitivity, Addison disease, hypercaliemia, hyperpotassiemia, concomitant intake with potassium supplements or other potassium-sparing diuretics such as Aldactazide, amiloride (Midamor, Moduretic), triamterene (Dyrenium, Dyazide, Maxzide), hyponatriemia, chronic kidney failure, diabetic nephropathy, anuria, liver failure, diabetes at supposed chronic kidney failure, diabetic nephropathy, pregnancy, and some others. Please take this medicine only if it is advised by your doctor.

Possible side effect

Side effects of the medicine include headache, diarrhea, cramps, drowsiness, rash, nausea, vomiting, impotence, irregular menstrual periods, and irregular hair growth. Fluid and electrolytes imbalance are likely, so patients should be monitored carefully. Enlargement of the breasts may also occur depending on dose and duration of therapy. This condition is usually reversible when you discontinue to take Aldactone.

Drug interaction

This medicine can lower blood sodium levels while raising blood potassium levels. Excessively high potassium levels in blood sometimes cause potentially life-threatening abnormalities in heart rhythm. Therefore, Aldactone usually is not administered with other agents that can raise blood potassium levels. Aldactone can cause elevation of blood digoxin (Lanoxin) to toxic levels.

Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose

Immediate medical attention in needed in case you overdosed intake of the medicine. Overdose symptoms may include drowsiness, confusion, red skin rash, nausea, vomiting, or diarrhea.

Storage

Aldactone should be stored at room temperature, below 25 C (77 F).

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment

Esidrix is a thiazide diuretic (water pill) that helps to prevent your body from absorbing too much salt, which can cause fluid retention. The fluid retention can occur in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking estrogens o steroids. Also the medicine is used for treating high blood pressure (hypertension).

Dosage and directions

Take Esidrix exactly as it was directed by your doctor.Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure this medication is not causing harmful effects, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled appointments.

Your blood and urine may both be tested if you have been vomiting or are dehydrated. If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms. Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

Precautions

Before taking Esidrix discuss with your doctor if you have kidney or liver disease, gout, allergies or asthma, diabetes or allergy to sulfa drugs.

Contraindications

Do not use the medicine if you have allergy to hydrochlorothiazide or if you are unable to urinate. Before using Esidrix, tell your doctor if you have liver or kidney disease, asthma or allergies, gout, diabetes or if you have allergy to sulfa drugs. Avoid drinking alcohol and becoming overheated or dehydrated during exercise in hot weather.

Possible side effects

Seek urgent medical help if you fell these sever side effects:allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using the medicine if you have signs of the following severe side effects: dry mouth, thirst, nausea, vomiting; feeling weak, drowsy, restless, or light-headed; fast or uneven heartbeat; muscle pain or weakness; numbness or tingly feeling; a red, blistering, peeling skin rash; or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects are: mild stomach pain, diarrhea, constipation or blurred vision.

Drug interaction

Before taking Esidrix tell your doctor if you are using lithium, steroids (prendisone), digoxin (Lanoxin), cholestyramine ( Questran, Prevalite) or colestipol (Colestid), other blood pressure medications, insulin or diabetes medicine taken by mouth, NSAIDs such as apirin, ibuprofen, diclofenac, indometacin, naproxen, piroxicam, nabumetone, etodolac and others.

Missed dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Overdose

Seek urgent medical attention if you think you have overdosed this medicine. Overdose symptoms may include nausea, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness.

Storage

Store at room temperature away from heat, light, and moisture.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Lozol is a thiazide-like diuretic which contains an active substance benzamide-sulfonamide-indole (Indapamide). By its pharmacological properties it is similar to thiazide diuretics (changes of Na+ re-absorption in the vertical segment of the loop of Henle). Lozol increases excretion of Na+, Cl-, K+, and Mg2+ with urine. It is used to treat hypertension either alone or in combination with other high blood pressure medications. Long treatment with Lozol is required, a therapeutic effect observed after 1-2 weeks of use, maximum is reached in 8-12 weeks and keeps up to 8 weeks.

Dosage and direction

Take Lozol once a day in mornings before breakfast with or without food. The usual initial dose is 1.25 mg taken as a single daily dose. It may be increased up to 5 mg.

Precautions

Lozol and other diuretics stimulate excretion of slats and potassium with urine which may lead to considerable loss of the substances especially among elderly women. Hypopotasse signs are muscle weakness and rapid or irregular heartbeat. For compensation of the potassium loss, you may be recommended to eat potassium-rich foods or taking a potassium supplement. Risk of hypopotassemia increases when larger doses are used, in the patients with cirrhosis, and in those treated by corticosteroids or ACTH. Blood pressure, K+ serum, and creatinine tests should be done regularly, especially in the individuals with an irregular heartbeat or those on heart medications. Systematic control of blood K+, Na+, Mg2+, pH, glucose uric acid and residual nitrogen is required especially in patients with gout or high uric acid levels, liver disease, diabetes, or lupus erythematosus, kidney dysfunction.

Contraindications

Lozol cannot be administered in patients with hypersensitivity to its components, severe liver or kidney failure (anuria), hypopotassemia. High doses of Lozol cannot be used to treat edematous syndrome in the patients with cerebrovascular accident and decompensated diabetes with ketoacidosis. Lozol cannot be used in individuals with lactose intolerance, galactosemia, a syndrome of glucose malabsorption for the medication which contain lactose. Cautiousness should be exercised in individuals with impairments of water-electrolyte balance, moderate liver or kidney failure, ascites, coronary artery disease, heart failure, hyperuricemia (gout), hyperparathyroidism, pregnant or breastfeeding women in elderly or adolescents under 18 years of age.

Possible side effect

Frequency of side effects depends on the dose of Lozol. They may appear as agitation, anxiety, dizziness, headache, back pain, diarrhea, vomiting, abdominal pain, dry mouth, infection, irritability, muscle cramps or spasms, numbness in hands and feet, nervousness, nasal inflammation, pain, tension, fatigue, weakness, loss of energy or tiredness.

Drug interaction

Lozol may cause hypopotasseimia and hypomagnesemia. Fatal arrhythmias may develop in patients on digoxin (Lanoxin) due to toxicity. Cardiac arrhythmias are also caused by use of amiodarone (Cordarone) and indapamide. Elimination of lithium by kidneys decreases in patients treated by diuretics and hereby leads to increase of lithium toxicity.

Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose

You need immediate medical attention in case of Lozol overdose which may express through such symptoms as electrolyte imbalance, nausea, stomach disorders, vomiting, weakness.

Storage

Tablets of Lozol should be stored at room temperature between 15-30 C (59-86 F).

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Microzide is a moderate thiazide diuretic medication which decreases reabsorbtion of Na+ at the level of cortical limb of Henles’ loop not influencing its segment located in medullary layer of the kidney. This is a reason of its weaker diuretic effect comparing to Lasix. Microzide is used to treat high blood pressure and accumulation of fluid (edema of different origin). Mechanism of its treating effect on lowering of high blood pressure is not well understood.

Dosage and direction

Microzide maybe taken with our without food and its dose depends on your condition, age and weight and should be prescribed by your doctor.

Precautions

Avoid drinking alcohol, becoming overheated or dehydrated during workouts, exercise and in hot weather. Warn your doctor if you suffer from liver disease, kidney disease, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs.

Contraindications

Hypersensitivity, diabetes, chronic kidney failure, anuria, severe liver failure Addison disease, first trimester of pregnancy, breastfeeding, infancy (younger than 3 y.o.).

Possible side effect

If you feel weakness, low blood pressure, light sensitivity, impotence, nausea, abdominal pain, electrolyte disturbances, pancreatitis, jaundice, anaphylaxis, and rashes contact your doctor and seek for immediate medical help. Patients allergic to Sulfa may also be allergic to Microzide.

Microzide can aggravate kidney dysfunction, lower blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to abnormalities in heart rhythm, so treatment with Microzide require supplementation with potassium is common to prevent low potassium levels.

Drug interaction

Concomitant treatment with ethanol, barbiturates, opioid analgesics increases risk of hypotension. If Microzide is administered with insulin and medications which decrease levels of sugar in blood correction of such medication may be needed. Microzide reduces the elimination of lithium by the kidneys. Nonsteroidal antiinflammatory drugs may reduce the blood pressure effects of Microzide.

Missed dose

If you forgot to take a dose take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.

Overdose

If you experience nausea, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness seek for immediate medical help.

Storage

Keep at room temperature, 15-30 C (59-86 F), in a light-resistant container away from moisture.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.