Retin-A Micro Gel has been approved for the treatment of acne vulgaris. The novel acne therapy entraps tretinoin, the active component in RETIN-A, in Microsponge systems (round tiny particles composed of synthetic polymer) and turns it into a gel. The medicine is held in reserve by the microspheres, allowing the skin to absorb tiny quantities of tretinoin over time. Dermatologists who conducted the key clinical trials believe this is why the majority of RETIN-A MICRO patients report little or no discomfort. When patients shower or wash their faces, the microspheres remain on top of their skin and are readily wiped away.